Does Alcohol Cause Inflammation? Here’s The Answer In 2025

Alcohol use disorder has been linked to acute and chronic diseases. But does alcohol cause inflammation directly? Alcohol intake is linked to a range of adverse health outcomes, from mental to physical symptoms. For example, alcohol affects anxiety but, yes, too much of it can also cause inflammation.

Acute inflammation is usually good because it’s your body’s response to fighting illnesses and healing injuries. However chronic inflammation from alcohol use disorder is more concerning because it contributes to organ, cell, and tissue damage. 

Want to understand how alcohol contributes to inflammation and how to reduce alcohol-induced inflammation? Read on to learn about the current research on alcohol consumption, inflammation, and the risks of being chronically inflamed. 

How Does Alcohol Contribute To Inflammation?

The alcohol and inflammation link is well established, but does vodka cause inflammation too? 

While alcohol can cause inflammation if consumed in large quantities, some research paradoxically suggests alcohol can help reduce pain such as arthritis symptoms.^[3] However, we don’t yet fully understand the mechanisms.

Alcohol contributes to inflammation in general:

Increasing Gut Permeability

Healthy intestines tightly regulate the absorption of certain substances into the body. Alcohol disrupts gut function,^[4] leading to increasing permeability of the intestinal lining. This increases the risk of your body absorbing partially digested and inflammatory foods, bacteria, or toxins into the bloodstream, causing inflammation.

This triggering of inflammation in the gastrointestinal tract^[5] can lead to systemic inflammation and damage to organs around the body.

Disrupting Gut Microbiome

Alcohol leads to an overgrowth of pathogenic bacteria in the gut, increasing the levels of bacterial toxins^[6] which further destroy the protective mucosal layer of the intestinal wall.

Because of the increased gut permeability, harmful bacteria can also enter the bloodstream and cause an inflammatory response in organs around the body. 

Translocating Lipopolysaccharide 

Lipopolysaccharide,^[7] also known as LPS, is a toxin present in the cell walls of some pathogenic bacteria. Long-term alcohol consumption damages the gut, liver, and other organs, partially by toxic LPS being absorbed into the body.

Suppressing Immune Function

Excessive alcohol consumption is strongly correlated with immune system-related health problems.^[8]

Under the stress of chronic alcohol consumption, the body becomes more vulnerable to illnesses like pneumonia, sepsis, alcoholic liver disease, some cancers, respiratory stress syndrome, and slow wound healing as the immune system deteriorates.

Effects Of Inflammation On Your Health

During acute inflammation, the immune system releases white blood cells to the affected area, causing symptoms such as redness and swelling. These symptoms are part of the healing process.

However, if this acute immune response fails to resolve the condition, inflammation may persist, leading to systematic chronic inflammation.

Here are some conditions that can be caused by inflammation:

Weakened Immune System

White blood cells commonly respond to inflammation and infections. According to research, alcohol disrupts these immune pathways,^[8] reducing the body’s ability to protect vital organs and damaged tissues from infection and disease. 

Chronic inflammation is linked to an increased white blood cell count by continually triggering an immune response. But more white blood cells don’t necessarily mean a better immune system. Research shows that the function of these white blood cells becomes compromised in heavy drinks, increasing the risk of viral and bacterial infections.

Cardiovascular And Heart Disease

A higher number of white blood cells is also associated with a higher risk of inflammatory diseases, especially cardiovascular disease, heart disease,^[9] and cancer. 

High inflammatory proteins^[10] called cytokines also increase the risk of cardiovascular disease. Inflammation in blood vessel walls raises blood pressure while decreasing blood flow in and out of the heart. This can result in chest pressure after light activities and increase the risk of a heart attack.

Arthritis And Other Chronic Pain Conditions

A high level of inflammatory cytokines increases joint inflammation^[11] and pain sensitization, which has a knock-on effect on your mental health, too. Inflammation is a common mechanism in rheumatoid arthritis,^[12] an autoimmune disease.

Other chronic pain conditions^[13] caused by chronic inflammation include Crohn’s disease, multiple sclerosis, and fibromyalgia.

Oddly, studies suggest that drinking alcohol is linked to lower odds of chronic pain.^[14] However, the relationship between alcohol, inflammation, and chronic pain is not yet fully understood.

Fatty Liver Disease

The breakdown of alcohol produces harmful substances^[15] that cause inflammation and can damage the liver. Chronic liver inflammation can lead to alcoholic fatty liver disease,^[16] which, if untreated, can eventually result in liver failure. 

Alcoholic fatty liver disease is, unfortunately, a self-fulfilling prophecy. Excessive fat stores in the liver impair its ability to convert alcohol to a form that can be safely removed from the body, leading to further liver damage.

Mental Illness

Excessive drinkers frequently suffer from mental health issues^[17] such as stress and depression. Conversely, researchers have found that optimists have lower levels of chronic inflammation^[18] and are less likely to be depressed.

Other mental health disorders that may be worsened by chronic inflammation include dementia,^[19] bipolar disorder,^[20] autism spectrum disorder,^[21] and post-traumatic stress disorder.^[22]

Tips To Reduce Alcohol-Related Inflammation

So many factors determine the effects of alcohol on your body, including sleep quality, hydration status, the type and amount of alcohol consumed, and overall physical health. Here are some tips to help you reduce the inflammatory potential of alcohol in your body.

Drink Less

Drinking less is the most obvious way to reduce alcohol-induced inflammation. Reducing your daily alcohol intake or drinking less often helps your body recover between drinks.

Try gradually changing your drinking habits to moderate alcohol consumption or, eventually, abstaining from alcohol consumption altogether. The Centers for Disease Control and Prevention^[23] recommends no more than one drink daily for women and two for men.  

When consumed in moderation, some studies suggest that alcohol might even be protective against inflammation.^[24]

Improve Your Diet

Many foods contain antioxidant and anti-inflammatory compounds, particularly colorful fruits and vegetables. Fruits and vegetables contain phytonutrients and fiber,^[25] beneficial plant nutrients that can help reduce inflammation. 

Spices with anti-inflammatory properties, such as ginger, turmeric, caraway, and rosemary, can also be used to season foods.

Avoid Drinking On An Empty Stomach

Eating before drinking slows gastric emptying,^[26] which is the movement of materials from the stomach to the small intestines. This slows down the rate of alcohol absorption, which can lessen the negative impact on your body. It also reduces alcohol addiction potential.

So, if you choose to drink alcohol, it is best to consume it with a meal. 

Manage Your Stress Levels

Chronic stress is associated with chronic low-grade inflammation.^[27] Both stress and alcohol consumption can trigger brain inflammation,^[28] which increases the likelihood of depression and other mental illnesses. 

Reduce your stress levels by minimizing alcohol intake, getting enough sleep,^[29] meditating, and practicing mindfulness.^[30]

The Worst Types Of Non-Alcoholic Drinks For Inflammation To Avoid

So you’ve decided to cut down on alcohol. What should you drink instead? Unfortunately, even some non-alcoholic drinks can trigger inflammation. These are the worst inflammation-inducing non-alcoholic drinks to avoid:

Soda

Drinking sugar-sweetened beverages such as sodas is associated with inflammation and obesity.^[31] Sodas contain sugar, flavors, sweeteners, artificial colors, and preservatives that might increase inflammation by damaging the gut microbiome.^[32]

Natural beverages like tea or flavored water are the best drinks for inflammation. Water can be enhanced with natural flavors such as lemon, cucumber, crushed fruit, or peppermint leaves.

Energy Drinks

Energy drinks are sodas with added vitamins and stimulants. They have a high sugar content and artificial ingredients that increase the risk of inflammatory diseases such as diabetes.

If you’re looking for an energy boost, try getting your caffeine hit from coffee or tea instead. When consumed in moderation, these drinks contain anti-inflammatory compounds that might help reduce inflammation^[33]. Avoid hot drinks laden with sugar, flavored syrups, and high-calorie cream, though!

Fruit Juices

Some fruit juices, such as orange juice, contain bioactive compounds that can help reduce inflammation.^[34] However, without the fiber and skin from the fruit, some cheap fruit juices are simply sugar-concentrated natural drinks that, if consumed in excess, might even worsen inflammation.

Many fruit juice brands contain added sugar, which is pro-inflammatory.^[35] Smoothies are a healthier option because they can include fruits, vegetables, and nuts, providing a more complete nutritional profile.

Flavored Coffee

Cappuccinos, lattes, and frappucinos are coffee drinks with added sugar, milk, flavored syrups, and cream. The high sugar and fat content may cause an inflammatory reaction. For a healthier alternative, flavor plain coffee or tea with vanilla, cinnamon, or low-fat milk.

Other Ways To Reduce Inflammation In the Body

Aside from alcohol, your diet, lifestyle, and genetics can also determine your risk of chronic inflammation. Try better managing your body’s inflammation levels by:

Changing Certain Medications

Nonsteroidal anti-inflammatory drugs^[36] such as aspirin and ibuprofen are commonly used to treat acute inflammation and alleviate short-term pain. For chronic inflammation, corticosteroids such as cortisol might be prescribed to alleviate symptoms. 

Fasting

Fasting reduces the number of inflammatory mediators^[37] in the blood. While it is impossible to fast indefinitely, intermittent fasting, such as eating within a certain timeframe, might help reduce chronic inflammation.

Try reducing the time window in which you eat each day, such as avoiding eating two to three hours before bedtime and eating breakfast two or more hours later than usual.

Meal replacement diet plans are also available to ensure adequate nutrient intake without overfeeding. 

Avoiding Inflammatory Foods

Processed sugar, red meat, and fried foods like french fries are well-known inflammatory foods.^[38] Grains like bread, pasta, rice, and flour are simple carbohydrates that quickly enter your bloodstream, spike your blood sugar, and lead to inflammation. Consume these foods sparingly. 

Exercising Regularly

Obesity puts strain on the body’s tissues and organs, causing inflammation.^[39] Moderate-intensity exercise like jogging, running, cycling, and swimming can aid weight loss while reducing chronic inflammation.^[40]

Supplementation

Supplements for inflammation, like green powders, are non-invasive and often less expensive than medication. For best results, look for safe substitutes for inflammatory foods and replace soft drinks with anti-inflammatory teas.

The Bottom Line

So, does alcohol cause inflammation? Yes, consuming alcohol can lead to constant, low-grade inflammation around the body. This chronic inflammation increases your risk of developing lifestyle diseases like diabetes, fatty liver, heart disease, inflammatory bowel disease, and cancer.

Some people are more susceptible to alcohol-induced inflammation than others. Genetics, diet, sleep quality, stress levels, medications, and body weight all play a role. Chronic inflammation requires lifestyle changes to improve, such as limiting your alcohol intake. 

Knowing what causes inflammation in your particular case can help you make informed decisions to manage better or reverse the condition.

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